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1

The Irwin Test and Functional Observational Battery (FOB) for Assessing the Effects of Compounds on Behavior, Physiology, and Safety Pharmacology in Rodents

Mathiasen, Joanne R., Moser, Virginia C.

Journal:

Current Protocols in Pharmacology

Year:

2018

Language:

english

File:

PDF, 532 KB

english, 2018

2

Mixed lineage kinase activity of indolocarbazole analogues

Chikara Murakata, Masami Kaneko, George Gessner, Thelma S Angeles, Mark A Ator, Teresa M O'Kane, Beth Ann W McKenna, Beth Ann Thomas, Joanne R Mathiasen, Michael S Saporito, Donna Bozyczko-Coyne, Robe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 164 KB

english, 2002

3

Prolactin Implants in the Hypothalamus Inhibit Prolactin Surges During Pregnancy and Alter Prolactin Release in Response to Dopamine Receptor Blockade

Gabriela Vidal, Joanne R. Mathiasen, James L. Voogt

Journal:

Journal of Neuroendocrinology

Year:

1991

Language:

english

File:

PDF, 431 KB

english, 1991

4

Central Administration of Serotonin Decreases Tyrosine Hydroxylase Catalytic Activity and Messenger Ribonucleic Acid Signal Levels in the Hypothalamus of Female Rats

Joanne R. Mathiasen, Lydia A. Arbogast, James L. Voogt

Journal:

Journal of Neuroendocrinology

Year:

1992

Language:

english

File:

PDF, 1.20 MB

english, 1992

5

Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy

Martin, Gregory E., Elgin, Robert J., Mathiasen, Joanne R., Davis, Coralie B., Kesslick, James M., Baldy, William J., Shank, Richard P., DiStefano, Deena L., Fedde, Cynthia L., Scott, Malcom K.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 562 KB

english, 1989

6

Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities

Hervé Schaffhauser, Joanne R. Mathiasen, Amy DiCamillo, Mark J. Huffman, Lily D. Lu, Beth A. McKenna, Jie Qian, Michael J. Marino

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 396 KB

english, 2009

7

Synthesis and evaluation of pyridazinone–phenethylamine derivatives as selective and orally bioavailable histamine H3 receptor antagonists with robust wake-promoting activity

Reddeppa reddy Dandu, John A. Gruner, Joanne R. Mathiasen, Lisa D. Aimone, Greg Hostetler, Caitlyn Benfield, Robert J. Bendesky, Val R. Marcy, Rita Raddatz, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 322 KB

english, 2011

8

Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H3 receptor antagonists

Nadine C. Becknell, Jacquelyn A. Lyons, Lisa D. Aimone, John A. Gruner, Joanne R. Mathiasen, Rita Raddatz, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 993 KB

english, 2011

9

4,5-Dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists

Robert L. Hudkins, Lisa D. Aimone, Reddeppa reddy Dandu, Derek Dunn, John A. Gruner, Zeqi Huang, Kurt A. Josef, Jacquelyn A. Lyons, Joanne R. Mathiasen, Ming Tao, Allison L. Zulli, Rita Raddatz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 699 KB

english, 2012

10

Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists

Babu G. Sundar, Thomas R. Bailey, Derek D. Dunn, Edward R. Bacon, Joseph M. Salvino, George C. Morton, Lisa D. Aimone, Huang Zeqi, Joanne R. Mathiasen, Amy Dicamillo, Mark J. Huffman, Beth A. McKenna,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 249 KB

english, 2012

11

Synthesis and structure–activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H3 receptor inverse agonists

Ming Tao, Lisa D. Aimone, John A. Gruner, Joanne R. Mathiasen, Zeqi Huang, Jacquelyn Lyons, Rita Raddatz, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 358 KB

english, 2012

12

Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: Identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test

Rabindranath Tripathy, Robert J. McHugh, Edward R. Bacon, Joseph M. Salvino, George C. Morton, Lisa D. Aimone, Zeck Huang, Joanne R. Mathiasen, Amy DiCamillo, Mark J. Huffman, Beth A. McKenna, Karla K

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 580 KB

english, 2012

13

4-Phenoxypiperidine pyridazin-3-one histamine H3 receptor inverse agonists demonstrating potent and robust wake promoting activity

Robert L. Hudkins, Allison L. Zulli, Reddeppa reddy Dandu, Ming Tao, Kurt A. Josef, Lisa D. Aimone, R. Curtis Haltiwanger, Zeqi Huang, Jacquelyn A. Lyons, Joanne R. Mathiasen, Rita Raddatz, John A. Gr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 408 KB

english, 2012

14

Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists

Allison L. Zulli, Lisa D. Aimone, Joanne R. Mathiasen, John A. Gruner, Rita Raddatz, Edward R. Bacon, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 686 KB

english, 2012

15

Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells

Joanne R. Mathiasen, Beth Ann W. McKenna, Michael S. Saporito, Ghanashyam D. Ghadge, Raymond P. Roos, Beverly P. Holskin, Zhi-Liang Wu, Stephen P. Trusko, Thomas C. Connors, Anna C. Maroney, Beth Ann

Journal:

Year:

2004

Language:

english

File:

PDF, 564 KB

english, 2004

16

Optimization of 5-Pyridazin-3-one Phenoxypropylamines as Potent, Selective Histamine H3 Receptor Antagonists with Potent Cognition Enhancing Activity

Tao, Ming, Aimone, Lisa D., Huang, Zeqi, Mathiasen, Joanne, Raddatz, Rita, Lyons, Jacquelyn, Hudkins, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 422 KB

english, 2012

17

Increased Vasopressin Secretion from Hypothalamic Cultures Following Administration of Exogenous Vasopressin mRNA

Joanne R. Mathiasen, Dominique Maciejewski-Lenoir, Floyd E. Bloom, Celia D. Sladek

Journal:

Experimental Neurology

Year:

1996

Language:

english

File:

PDF, 382 KB

english, 1996

18

μ-, but not δ-, opioid receptor-mediated antinociception in mice is attenuated by γ-irradiation

Robert B. Raffa, Joanne R. Mathiasen, Darrell Q. Brown

Journal:

Year:

1988

Language:

english

File:

PDF, 489 KB

english, 1988

19

[D-Pen2,L-Pen5]enkephalin induced analgesia in the jimpy mouse: in vivo evidence for δ-receptor mediated analgesia

Joanne R. Mathiasen, Jeffry L. Vaught

Journal:

European Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 231 KB

english, 1987

20

Restoration of analgesic response of C57BL/6J-bgJ (beige-J) mice to morphine by carbachol

Robert B. Raffa, Joanne R. Mathiasen, Jeffry L. Vaught

Journal:

European Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 276 KB

english, 1987

21

Block of conditioned avoidance responding in the rat by substituted phenylpiperazines

Gregory E. Martin, Robert J. Elgin Jr., James M. Kesslick, William J. Baldy, Joanne R. Mathiasen, Richard P. Shank, Malcolm K. Scott

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 467 KB

english, 1988

22

Central administration of p-octopamine to mice: assessment of antinociception

Robert B. Raffa, Joanne R. Mathiasen, Tamara L. Goode

Journal:

European Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 249 KB

english, 1989

23

Discovery and Characterization of 6-{4-[3-( R )-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2 H -pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H 3 Receptor Inverse Agonist

Hudkins, Robert L., Raddatz, Rita, Tao, Ming, Mathiasen, Joanne R., Aimone, Lisa D., Becknell, Nadine C., Prouty, Catherine P., Knutsen, Lars J. S., Yazdanian, Mehran, Moachon, Gilbert, Ator, Mark A.,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1007 KB

english, 2011

24

C57BL/6J-bgJ (beige) mice: Differential sensitivity in the tail flick test to centrally administered MU- and delta-opioid receptor agonists

Joanne R. Mathiasen, Robert B. Raffa, Jeffry L. Vaught

Journal:

Year:

1987

Language:

english

File:

PDF, 303 KB

english, 1987

25

Colonic bead expulsion time in normal and μ-opioid receptor deficient (CXBK) mice following central (ICV) administration of μ- and δ-opioid agonists

Robert B. Raffa, Joanne R. Mathiasen, Henry I. Jacoby

Journal:

Year:

1987

Language:

english

File:

PDF, 298 KB

english, 1987

26

Evidence that reciprocal hindlimb scratching elicited in mice by intrathecal administration of muscarinic agonists is mediated through M1 type receptors

Robert B. Raffa, Joanne R. Mathiasen, Tamara L. Goode, Jeffry L. Vaught

Journal:

Year:

1987

Language:

english

File:

PDF, 291 KB

english, 1987

27

The analgesic defect of C57BL/6J-bgJ/bgJ (beige-J; Chediak-Higashi syndrome) mice transmitted by adoptive transfer of spleen cells to normal littermates

Robert B. Raffa, Edward S. Kimball, Joanne R. Mathiasen

Journal:

Year:

1988

Language:

english

File:

PDF, 314 KB

english, 1988

28

The combined immunological and anticociceptive defects of beige-J mice: The possible existence of A ‘μ-repressin’

Robert B. Raffa, Joanne R. Mathiasen, Edward S. Kimball, Jeffrey L. Vaught

Journal:

Year:

1993

Language:

english

File:

PDF, 448 KB

english, 1993

29

[3H][D-Ala2,NMePhe4,Gly-ol5]-enkephalin (mu-opioid) binding in beige-J mice

Raffa, Robert B., Baldy, William J., Shank, Richard P., Mathiasen, Joanne R., Vaught, Jeffry L.

Journal:

Year:

1988

Language:

english

File:

PDF, 555 KB

english, 1988

30

Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): Histamine H3 receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity

Hudkins, Robert L., Josef, Kurt A., Becknell, Nadine C., Aimone, Lisa D., Lyons, Jacquelyn A., Mathiasen, Joanne R., Gruner, John A., Raddatz, Rita

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 582 KB

english, 2014

31

The effect of Phe-Met-Arg-Phe-NH2 (FMRFamide) on morphine-induced inhibition of colonic propulsive motility in mice

Jacoby, Melissa B., Jacoby, Henry I., Mathiasen, Joanne R., Raffa, Robert B.

Journal:

Neuroscience Letters

Year:

1987

Language:

english

File:

PDF, 300 KB

english, 1987

32

3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity

Hudkins, Robert L., Becknell, Nadine C., Lyons, Jacquelyn A., Aimone, Lisa D., Olsen, Mark, Haltiwanger, R. Curtis, Mathiasen, Joanne R., Raddatz, Rita, Gruner, John A.

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 639 KB

english, 2015

33

3-(1′-Cyclobutylspiro[4H-1,3-benzodioxine-2,4′-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist

Hudkins, Robert L., Gruner, John A., Raddatz, Rita, Mathiasen, Joanne R., Aimone, Lisa D., Marino, Michael J., Bacon, Edward R., Williams, Michael, Ator, Mark A.

Journal:

Neuropharmacology

Year:

2015

Language:

english

File:

PDF, 787 KB

english, 2015

34

Effects of Bepridil Hydrochloride on Cardiocirculatory Dynamics, Coronary Vascular Resistance, and Cardiac Output Distribution in Normal, Conscious Rats

Flaim, Stephen F., Stranieri, Maria T., Mathiasen, Joanne R.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1988

File:

PDF, 714 KB

1988

35

Some Problems of Admiralty Jurisdiction in the 17th Century

Joanne Mathiasen

Journal:

The American Journal of Legal History

Year:

1958

Language:

english

File:

PDF, 9.22 MB

english, 1958

36

Effects of Mefenidil Hydrochloride on Cerebral Blood Flow in Conscious and Anesthetized Rat

Flaim, Stephen F., Stranieri, Maria T., Mathiasen, Joanne R., Brannan, Melvin D.

Journal:

Year:

1986

Language:

english

File:

PDF, 1.73 MB

english, 1986

37

Differential Regulation of the Nocturnal and Diurnal Prolactin Surges in Pregnant Rats Revealed by Dopamine Receptor Antagonism

Mathiasen, Joanne R., Voogt, James L.

Journal:

Neuroendocrinology

Year:

1992

Language:

english

File:

PDF, 1.52 MB

english, 1992